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Intorduction

Renal Cancer

Renal cancer is a malignant tumor that originates from the urinary tubule epithelial system of the renal parenchyma. The full academic term is renal cell carcinoma, also known as renal adenocarcinoma, or renal cancer for short. Including various renal cell carcinoma subtypes originating in different parts of the urinary tubules, but not including tumors derived from the renal interstitium and renal pelvis tumors. As early as 1883, the German pathologist Grawitz, based on the appearance of adrenal cells under a microscope, proposed that kidney cancer is the origin of adrenal gland tissue remaining in the kidney. Therefore, in the books before the reform and opening up in my country, kidney cancer was called Grawitz. Tumor or adrenoid tumor. It was not until 1960 that Oberling, based on electron microscope observations, suggested that kidney cancer originated from the proximal tubules of the kidney and corrected this error.

Symptoms

Low back pain, hematuria, abdominal mass



Hypertension, anemia, weight loss, cachexia, fever, polycythemia, abnormal liver function


Hypercalcemia, hyperglycemia, increased erythrocyte sedimentation rate, neuromuscular disease, amyloidosis, galactorrhea, abnormal blood coagulation mechanism



Bone pain, fracture, cough, hemoptysis, etc.

ACTL Treatment Plan

After determining the indications for ACTL treatment of patients in accordance with the "Screening Criteria for Cancer Patients", the specific ACTL treatment plan should be determined according to the specific conditions of the patient, such as the patient's condition, receiving radiotherapy and chemotherapy, and the following principles should be mastered:

1. The patient should have blood routine, liver and kidney function, relevant serum tumor markers (tumor antigen or tumor-related antigen) laboratory test and imaging examination results.

2. During ACTL treatment, in addition to treatments that damage immune function or bone marrow suppression, patients can receive other anti-tumor treatments.

3. The number of antigen-specific cytotoxic T Iymphocytes (CTL) of patients who are reinfused in each treatment should be ≥1*108

4. For patients with allergies or elderly and infirm, when CTL is reinfused, a small dose of dexamethasone can be considered.

5. Clinical therapeutic grade interleukin 2 (IL-2): At the same time as CTL is reinfused, intravenous infusion of IL-2 is recommended to adjust the patient's immune function, prolong the activity of CTL in the body, and improve the efficiency of killing tumor cells. For the first reinfusion, the recommended dose is 500,000 units to observe the patient's tolerance to IL-2. If the patient has no obvious adverse reactions or allergic reactions, from the second ACTL treatment, 1 to 2 million units of IL-2 will be given each time CTL is infused. It is not recommended to use my country's SFDA approved for clinical treatment

After determining the indications for ACTL treatment of patients in accordance with the "Screening Criteria for Cancer Patients", the specific ACTL treatment plan should be determined according to the specific conditions of the patient, such as the patient's condition, receiving radiotherapy and chemotherapy, and the following principles should be mastered:

1. The patient should have blood routine, liver and kidney function, relevant serum tumor markers (tumor antigen or tumor-related antigen) laboratory test and imaging examination results.

2. During ACTL treatment, in addition to treatments that damage immune function or bone marrow suppression, patients can receive other anti-tumor treatments.

3. The number of antigen-specific cytotoxic T Iymphocytes (CTL) of patients who are reinfused in each treatment should be ≥1*108

4. For patients with allergies or elderly and infirm, when CTL is reinfused, a small dose of dexamethasone can be considered.

5. Clinical therapeutic grade interleukin 2 (IL-2): At the same time as CTL is reinfused, intravenous infusion of IL-2 is recommended to adjust the patient's immune function, prolong the activity of CTL in the body, and improve the efficiency of killing tumor cells. For the first reinfusion, the recommended dose is 500,000 units to observe the patient's tolerance to IL-2. If the patient has no obvious adverse reactions or allergic reactions, from the second ACTL treatment, 1 to 2 million units of IL-2 will be given each time CTL is infused. It is not recommended to use my country's SFDA approved for clinical treatment

After determining the indications for ACTL treatment of patients in accordance with the "Screening Criteria for Cancer Patients", the specific ACTL treatment plan should be determined according to the specific conditions of the patient, such as the patient's condition, receiving radiotherapy and chemotherapy, and the following principles should be mastered:

1. The patient should have blood routine, liver and kidney function, relevant serum tumor markers (tumor antigen or tumor-related antigen) laboratory test and imaging examination results.

2. During ACTL treatment, in addition to treatments that damage immune function or bone marrow suppression, patients can receive other anti-tumor treatments.

3. The number of antigen-specific cytotoxic T Iymphocytes (CTL) of patients who are reinfused in each treatment should be ≥1*108

4. For patients with allergies or elderly and infirm, when CTL is reinfused, a small dose of dexamethasone can be considered.

5. Clinical therapeutic grade interleukin 2 (IL-2): At the same time as CTL is reinfused, intravenous infusion of IL-2 is recommended to adjust the patient's immune function, prolong the activity of CTL in the body, and improve the efficiency of killing tumor cells. For the first reinfusion, the recommended dose is 500,000 units to observe the patient's tolerance to IL-2. If the patient has no obvious adverse reactions or allergic reactions, from the second ACTL treatment, 1 to 2 million units of IL-2 will be given each time CTL is infused. It is not recommended to use my country's SFDA approved for clinical treatment

  • I. Patients with stage II tumors

    1. Patients who are receiving radiotherapy and chemotherapy are not recommended to receive ACTL treatment at the same time;

    2. For patients who are going to receive radiotherapy or chemotherapy, consider the following ACTL treatment plan, but pay attention to the obvious decline in the number of white blood cells or bone marrow suppression, and stop ACTL treatment;

    1. Patients who are receiving radiotherapy and chemotherapy are not recommended to receive ACTL treatment at the same time;

    2. For patients who are ready to receive radiotherapy or chemotherapy, consider the following ACTL treatment plan, but pay attention to the obvious decline in the number of white blood cells or bone marrow suppression, and stop ACTL treatment;

    1. Patients who are receiving radiotherapy and chemotherapy are not recommended to receive ACTL treatment at the same time;

    2. For patients who are going to receive radiotherapy or chemotherapy, consider the following ACTL treatment plan, but pay attention to the obvious decline in the number of white blood cells or bone marrow suppression, and stop ACTL treatment;

    1. Patients who are receiving radiotherapy and chemotherapy are not recommended to receive ACTL treatment at the same time;

    2. For patients who are going to receive radiotherapy or chemotherapy, consider the following ACTL treatment plan, but pay attention to the obvious decline in the number of white blood cells or bone marrow suppression, and stop ACTL treatment;

  • III. Patients with stage IV tumors

    1. Patients who are receiving radiotherapy and chemotherapy are not recommended to receive ACTL treatment at the same time;

    2. For patients who are going to receive radiotherapy or chemotherapy, consider the following ACTL treatment plan, but pay attention to the obvious decline in the number of white blood cells or bone marrow suppression, and stop ACTL treatment;

    1. Patients who are receiving radiotherapy and chemotherapy are not recommended to receive ACTL treatment at the same time;

    2. For patients who are ready to receive radiotherapy or chemotherapy, consider the following ACTL treatment plan, but pay attention to the obvious decline in the number of white blood cells or bone marrow suppression, and stop ACTL treatment;

    1. Patients who are receiving radiotherapy and chemotherapy are not recommended to receive ACTL treatment at the same time;

    2. For patients who are going to receive radiotherapy or chemotherapy, consider the following ACTL treatment plan, but pay attention to the obvious decline in the number of white blood cells or bone marrow suppression, and stop ACTL treatment;

    1. Patients who are receiving radiotherapy and chemotherapy are not recommended to receive ACTL treatment at the same time;

    2. For patients who are going to receive radiotherapy or chemotherapy, consider the following ACTL treatment plan, but pay attention to the obvious decline in the number of white blood cells or bone marrow suppression, and stop ACTL treatment;

  • Patients who have finished radiotherapy and chemotherapy

    1. Patients who are receiving radiotherapy and chemotherapy are not recommended to receive ACTL treatment at the same time;

    2. For patients who are going to receive radiotherapy or chemotherapy, consider the following ACTL treatment plan, but pay attention to the obvious decline in the number of white blood cells or bone marrow suppression, and stop ACTL treatment;

    1. Patients who are receiving radiotherapy and chemotherapy are not recommended to receive ACTL treatment at the same time;

    2. For patients who are ready to receive radiotherapy or chemotherapy, consider the following ACTL treatment plan, but pay attention to the obvious decline in the number of white blood cells or bone marrow suppression, and stop ACTL treatment;

    1. Patients who are receiving radiotherapy and chemotherapy are not recommended to receive ACTL treatment at the same time;

    2. For patients who are going to receive radiotherapy or chemotherapy, consider the following ACTL treatment plan, but pay attention to the obvious decline in the number of white blood cells or bone marrow suppression, and stop ACTL treatment;

    1. Patients who are receiving radiotherapy and chemotherapy are not recommended to receive ACTL treatment at the same time;

    2. For patients who are going to receive radiotherapy or chemotherapy, consider the following ACTL treatment plan, but pay attention to the obvious decline in the number of white blood cells or bone marrow suppression, and stop ACTL treatment;

  • Patients receiving radiotherapy and chemotherapy

    1. Patients who are receiving radiotherapy and chemotherapy are not recommended to receive ACTL treatment at the same time;

    2. For patients who are going to receive radiotherapy or chemotherapy, consider the following ACTL treatment plan, but pay attention to the obvious decline in the number of white blood cells or bone marrow suppression, and stop ACTL treatment;

    1. Patients who are receiving radiotherapy and chemotherapy are not recommended to receive ACTL treatment at the same time;

    2. For patients who are ready to receive radiotherapy or chemotherapy, consider the following ACTL treatment plan, but pay attention to the obvious decline in the number of white blood cells or bone marrow suppression, and stop ACTL treatment;

    1. Patients who are receiving radiotherapy and chemotherapy are not recommended to receive ACTL treatment at the same time;

    2. For patients who are going to receive radiotherapy or chemotherapy, consider the following ACTL treatment plan, but pay attention to the obvious decline in the number of white blood cells or bone marrow suppression, and stop ACTL treatment;

    1. Patients who are receiving radiotherapy and chemotherapy are not recommended to receive ACTL treatment at the same time;

    2. For patients who are going to receive radiotherapy or chemotherapy, consider the following ACTL treatment plan, but pay attention to the obvious decline in the number of white blood cells or bone marrow suppression, and stop ACTL treatment;

  • Patients with severe disease and rapid progress

    1. Patients who are receiving radiotherapy and chemotherapy are not recommended to receive ACTL treatment at the same time;

    2. For patients who are going to receive radiotherapy or chemotherapy, consider the following ACTL treatment plan, but pay attention to the obvious decline in the number of white blood cells or bone marrow suppression, and stop ACTL treatment;

    1. Patients who are receiving radiotherapy and chemotherapy are not recommended to receive ACTL treatment at the same time;

    2. For patients who are ready to receive radiotherapy or chemotherapy, consider the following ACTL treatment plan, but pay attention to the obvious decline in the number of white blood cells or bone marrow suppression, and stop ACTL treatment;

    1. Patients who are receiving radiotherapy and chemotherapy are not recommended to receive ACTL treatment at the same time;

    2. For patients who are going to receive radiotherapy or chemotherapy, consider the following ACTL treatment plan, but pay attention to the obvious decline in the number of white blood cells or bone marrow suppression, and stop ACTL treatment;

    1. Patients who are receiving radiotherapy and chemotherapy are not recommended to receive ACTL treatment at the same time;

    2. For patients who are going to receive radiotherapy or chemotherapy, consider the following ACTL treatment plan, but pay attention to the obvious decline in the number of white blood cells or bone marrow suppression, and stop ACTL treatment;

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