《Immunity》 published a study titled "Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors". Scientists have proposed to improve the immune system's anti-cancer ability by reducing oxidized lipid damage in killer T cells, and identifying factors that cause immunosuppression in the tumor microenvironment can help develop new cancer immunotherapies.

        The team worked with Joseph Witztum's laboratory at the University of California, San Diego, and determined that tumors contain large amounts of lipids, especially oxidized lipids, which are usually found in oxidized low-density lipoproteins (low-density lipoproteins) and are generally considered It is "bad" fat. Then, they observed how killer T cells respond to oxidized low-density lipoproteins in tumors, and found that killer T cells increase CD36 (the scavenger receptor for oxidized lipids) on their surface and take up large amounts of oxidized lipids. Quality to adapt to the tumor microenvironment. In collaboration with Brinda Emu's laboratory at Yale University, they discovered that this process can act as a catalyst to drive more lipid oxidation inside killer T cells and ultimately inhibit their defenses.



Reference materials:
https://www.cell.com/immunity/fulltext/S1074-7613(21)00209-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761321002090%3Fshowall%3Dtrue


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