The clinical significance of squamous cell carcinoma antigen (SCC)

        A tumor marker for detecting squamous cell carcinoma with high specificity but low sensitivity.

1. Screening
        Serum SCC is generally not used for screening of cervical squamous cell carcinoma and lung squamous cell carcinoma.

2. Auxiliary diagnosis
        ① Serum SCC is a tumor marker mainly used to assist in the diagnosis of squamous cell carcinoma. It will increase in the serum of patients with cervical squamous cell carcinoma and lung squamous cell carcinoma, and its concentration will increase with the severity of the disease.
        ② Serum SCC also has varying degrees of positive rates in other malignant tumors, such as head and neck epithelial cell carcinoma, esophageal cancer, nasopharyngeal carcinoma, and skin cancer.
        ③ Serum SCC may also increase to varying degrees in certain benign diseases, such as hepatitis, liver cirrhosis, pneumonia, tuberculosis, psoriasis, eczema, renal failure, etc., but the positive percentage is low.

3. Prognosis assessment
        It is generally believed that elevated serum SCC is a risk factor for poor prognosis of cervical squamous cell carcinoma and lung squamous cell carcinoma. However, it is not recommended that SCC be routinely used in the prognosis of cervical squamous cell carcinoma and lung squamous cell carcinoma.

4. Efficacy and recurrence monitoring
        ① Elevated serum SCC is related to cervical squamous cell carcinoma lymph node metastasis, and can be used for the formulation of personalized treatment plans for cervical squamous cell carcinoma, but it is not currently used as a routine application.
        ② Serum SCC concentration is related to the staging of cervical squamous cell carcinoma, tumor size, residual tumor after surgery, tumor recurrence and progression, etc. Therefore, it can be used for the efficacy evaluation, follow-up and recurrence monitoring of cervical cancer.
        ③ Serum SCC has a certain value in monitoring the efficacy of lung squamous cell carcinoma.