With the approval of Premier Li Keqiang, the State Council recently issued the "Thirteenth Five-Year" National Science and Technology Innovation Plan (Guofa [2016] No. 43, hereinafter referred to as the "Plan"), which clearly put forward the guiding ideology, Overall requirements, strategic tasks and reform measures.

The full text of the "Plan" is nearly 70,000 words, and biomedicine is mentioned more than 30 times. It points out that by continuously conquering key core technologies such as new drug creation and infectious disease prevention and control, we will strengthen the prevention and control of major infectious diseases, accelerate the modernization of Chinese medicine services and the development of the health industry, and accelerate the progress Digital diagnosis and treatment equipment is localized, high-end, and branded, to build a high-level scientific and technological innovation base, and focus on solving major scientific and technological problems that restrict economic and social development and national security. At the same time, supporting policies have been given to related fields.

1. Major new drug creation

Focusing on 10 types (species) of major diseases such as malignant tumors and cardiovascular and cerebrovascular diseases, strengthen the development of major vaccines and antibodies, and focus on supporting the development of drugs that are innovative, effective, meet important needs, have major industrialization prospects, and have major commonalities. Technical and basic research capabilities, strengthen resource sharing and open services on innovation platforms, basically establish a national drug innovation system with the world’s advanced level, and the comprehensive capabilities and overall level of new drug research and development have entered the international advanced ranks, and accelerate China’s transformation from a major pharmaceutical country to a pharmaceutical Power transformation.

2. Prevention and treatment of major infectious diseases

Break through the comprehensive prevention and control technology of sudden acute infectious diseases, and improve the emergency response technology capabilities; overcome the key technologies and products for the diagnosis and prevention of hepatitis B and tuberculosis, strengthen vaccine research, develop a batch of advanced detection and diagnosis products, and improve the effectiveness of clinical treatment programs for hepatitis B and tuberculosis. Form a special treatment plan of Chinese medicine.

3. Health protection technology

Focusing on the needs of building a healthy China, strengthen the research and development of precision medicine and other technologies, deploy the prevention and control of chronic non-communicable diseases, common and frequently-occurring diseases, and research on the prevention and control of reproductive health and birth defects, accelerate the transfer and transformation of technological achievements, and promote demonstration services that benefit the people. In the field of biology and health, an overall layout covering major disease prevention and treatment, basic health care services and breakthroughs in cutting-edge medical technology will be formed; professional and popular demonstration applications will be realized in medical and other industries, and virtual reality and augmented reality industries will be cultivated.

4. New biomedical technology

Carry out research on key technologies such as major vaccines, antibody development, immunotherapy, gene therapy, cell therapy, stem cells and regenerative medicine, human microbiome analysis and regulation, and develop a batch of innovative pharmaceutical and biological products to build an internationally competitive pharmaceutical biotechnology industry system.

5. Biomedical materials

With the orientation of tissue replacement, functional repair, and intelligent regulation, we will accelerate breakthroughs in key technologies such as 3D bioprinting, biofunctionalization and modification of material surfaces, and new-generation biomaterial inspection and evaluation methods. The key layout can be organized to induce biomedical materials and tissue engineering products. , A new generation of implanted interventional medical devices, artificial organs and other major strategic products, improve the standards of medical-grade basic raw materials, build a new generation of biomedical material product innovation chain, and enhance the competitiveness of the biomedical materials industry.

6. Prevention and control of major diseases

Focus on major chronic diseases such as cardiovascular and cerebrovascular diseases, malignant tumors, metabolic diseases, respiratory system diseases, mental nervous system diseases, common and frequently-occurring diseases such as digestion, oral cavity, eyes, ears, nose and throat, and parasitic diseases such as hydatid, malaria, and schistosomiasis. As well as injury prevention and treatment technologies, strengthen the integrated layout of basic research, clinical transformation, evidence-based evaluation, and demonstration applications, break through a batch of key prevention and treatment technologies, develop a batch of new diagnosis and treatment plans, promote a batch of appropriate technologies, and effectively solve clinical problems And improve the level of grassroots service.

7. Key technologies of precision medicine

Grasp the development opportunities of the integration of biotechnology and information technology, establish a forward-looking cohort of millions of healthy people and patients with key diseases, establish a multi-level precision medical knowledge base system and a national biomedical big data sharing platform, and focus on the next generation of gene sequencing technology and omics Research and big data fusion analysis technology and other precision medical core key technologies, develop a batch of precision application solutions and decision support systems for early screening of major diseases, molecular classification, individualized treatment, curative effect prediction and monitoring, and promote medical diagnosis and treatment models change.

8. Digital diagnosis and treatment equipment

In the direction of early, accurate, and minimally invasive diagnosis and treatment, we will focus on advancing multimodal molecular imaging, new magnetic resonance imaging systems, new x-ray computed tomography, new generation ultrasound imaging, low-dose x-ray imaging, compound speculum imaging, and new display The development of micro-imaging, large-scale radiotherapy equipment, surgical robots, medical active implantable devices and other products will accelerate the localization, high-end and branding of digital diagnosis and treatment equipment.

9. In vitro diagnostic products

Break through key technologies such as microfluidic chips, single-molecule detection, and automated nucleic acid detection, develop automatic nucleic acid detection systems, high-throughput liquid-phase suspension chips, medical biological mass spectrometers, rapid pathological diagnosis systems and other major products, and develop a batch of major diseases Early diagnosis and precise treatment diagnostic reagents and high-precision diagnostic products suitable for primary medical institutions will enhance the competitiveness of my country's in vitro diagnostic industry.

10. Key technologies for health promotion

Aiming at quantitative monitoring and precise intervention, focusing on health status identification, health risk early warning, health autonomous intervention and other links, focusing on key technologies and products such as non-invasive detection, wearable monitoring, biosensing, health IoT, and health risk factor intervention , Strengthen the construction of the national physical fitness monitoring network, build a health big data cloud platform, develop digital and personalized behavior/psychological intervention, energy/nutrition balance, functional compensation/enhancement and other health management solutions, and accelerate the breakthrough of key technologies for active health and health Research on closed-loop management services.

11. Health Service Technology

Promote the integration and innovation of information technology and medical and health services, break through key technologies such as network collaboration and distributed support systems, formulate and improve privacy protection and information security standards and technical specifications, and establish an integrated, integrated, multidisciplinary collaboration based on information sharing, knowledge integration, and multidisciplinary collaboration. Continuous disease diagnosis and treatment and health management service model, promote the "Internet +" health and medical technology demonstration action, to achieve the goal of optimizing resource allocation, improving medical treatment mode and strengthening health promotion.

12. Drug quality and safety

Aiming at the needs of clinical medications, improving the consistency evaluation technical system of chemical generic drugs, carrying out the quality and efficacy evaluation of high-risk varieties, children's medications, and auxiliary medications, as well as research on the monitoring and evaluation of adverse drug reactions, and drug quality control, so as to improve the medication of Chinese residents Ensure the level of protection and enhance the ability to prevent and control drug safety risks.

13. Reproductive health and birth defect prevention and control

Solve outstanding problems in the prevention and control of birth defects, infertility, contraception and birth control in my country, establish a nationwide population cohort of childbearing age and births, establish a national biological information and sample resource database, and develop a batch of grassroots suitable technologies and innovative products , To comprehensively improve the scientific and technological level of birth defect prevention and control, ensure the reproductive health of the population of childbearing age, and improve the quality of the birth population.

14. Modernization of Traditional Chinese Medicine

Strengthen the original theoretical innovation of traditional Chinese medicine and modern inheritance research of traditional Chinese medicine, accelerate the objectification of the four diagnosis of traditional Chinese medicine, prevent diseases with traditional Chinese medicine, ecological planting of traditional Chinese medicines, and precision use of traditional Chinese medicine compounds, and formulate a batch of traditional Chinese medicines to prevent and treat major diseases and difficulties Clinical programs for diseases, develop a batch of TCM health products, upgrade the level of international scientific and technological cooperation in TCM, accelerate the modernization of TCM services and the development of the big health industry.

15. Build a high-level scientific and technological innovation base

Closely focusing on national strategic needs, vigorously promote the construction of scientific and technological innovation bases led by national laboratories. The technological innovation category includes scientific research bases formed after optimization and integration such as the National Technology Innovation Center and the National Clinical Medical Research Center. Support the construction of several scientific and technological innovation platforms in areas such as biomedicine and integrated circuits to form high-tech industrial clusters with international competitiveness.

16. "One Belt One Road" and the strategic opportunities of traditional Chinese medicine and ethnic medicine

Strengthen cooperative research with countries along the “Belt and Road” and actively carry out cooperative research on major scientific issues and coping with common challenges. Promote joint development of biological resources and promotion of health services in the fields of Chinese medicine and ethnic medicine. Strengthen cooperative development and industrial demonstration in the fields of biomedicine and other fields to enhance the innovation capability of my country's key industries.